A Personalized Molecular Approach for the Prevention and
Treatment of necrotizing enterocolitis
David J. Hackam, MD, PhD, FACS
Pediatric Surgeon-in-Chief and
Co-Director, Johns Hopkins Children’s Center
Garrett Professor and Chief of
Pediatric Surgery,
Professor of Surgery, Pediatrics
and Cell Biology,
Johns Hopkins University School of
Medicine
Objectives
1. To understand the five clinical presentations of
necrotizing enterocolitis in premature infants
2. To understand the pathogenesis of NEC based upon
host-microbial signaling and the activation of toll like receptor 4 (TLR4)
3. To understand emerging personalized treatments for NEC
based upon an understanding of the molecular mechanisms that contribute to
disease pathology.
REFERENCES
1: Kovler ML, Gonzalez Salazar AJ, Fulton WB, Lu P,
Yamaguchi Y, Zhou Q, Sampah
M, Ishiyama A, Prindle T Jr, Wang S, Jia H, Wipf P, Sodhi
CP, Hackam DJ. Toll-
like receptor 4-mediated enteric glia loss is critical for
the development of
necrotizing enterocolitis. Sci Transl Med. 2021 Sep
22;13(612):eabg3459. doi:
10.1126/scitranslmed.abg3459. Epub 2021 Sep 22. PMID:
34550727.
2: Sampah MES, Hackam DJ. Prenatal Immunity and Influences
on Necrotizing
Enterocolitis and Associated Neonatal Disorders. Front Immunol.
2021 Apr
21;12:650709. doi: 10.3389/fimmu.2021.650709. PMID:
33968047; PMCID: PMC8097145.
3: Lu P, Yamaguchi Y, Fulton WB, Wang S, Zhou Q, Jia H,
Kovler ML, Salazar AG,
Sampah M, Prindle T Jr, Wipf P, Sodhi CP, Hackam DJ.
Maternal aryl hydrocarbon
receptor activation protects newborns against necrotizing
enterocolitis. Nat
Commun. 2021 Feb 15;12(1):1042. doi:
10.1038/s41467-021-21356-4. PMID: 33589625;
PMCID: PMC7884836.
